May 13, 2020

IBRI RESEARCH PUBLISHED: Pancreatic ß-cells in Type 1 and Type 2 Diabetes Mellitus: Different Pathways to Failure

Abstract: Loss of functional β-cell mass is the key mechanism leading to the two main forms of diabetes mellitus — type 1 diabetes mellitus (T1DM) and type 2 diabetes...

April 16, 2020

IBRI IN THE NEWS: IBRI Names Scientific Director

INDIANAPOLIS - The Indiana Biosciences Research Institute has named Investigator Decio Eizirik as Scientific Director of the IBRI Diabetes Center. Eizirik will focus on recruiting early career investigators and defining...

April 15, 2020

IBRI Names Decio Eizirik Scientific Director of its IBRI Diabetes Center

INDIANAPOLIS, IND. – The Indiana Biosciences Research Institute (IBRI) is pleased to announce that it has named Investigator Decio Eizirik, MD, PhD, Scientific Director of its IBRI Diabetes Center (IDC)....

April 13, 2020

IBRI RESEARCH PUBLISHED: The T1D-associated lncRNA Lnc13 modulates human pancreatic ß cell inflammation by allele-specific stabilization of STAT1 mRNA

The mechanisms by which autoimmunity is amplified in type 1 diabetes (T1D) remain to be clarified, and the lack of this understanding hampers efforts to prevent or arrest the disease....

March 30, 2020

IBRI RESEARCH PUBLISHED: Hypusinated eIF5A is expressed in the pancreas and spleen of individuals with type 1 and type 2 diabetes

ABSTRACT The gene encoding eukaryotic initiation factor 5A ( EIF5A ) is found in diabetes-susceptibility loci in mouse and human. eIF5A is the only protein known to contain hypusine...

March 31, 2020

IBRI RESEARCH PUBLISHED: Utilization of Electronic Health Records for the Assessment of Adiponectin Receptor Autoantibodies during the Progression of Cardio-metabolic Comorbidities

ABSTRACT Background : Diabetes is a complex, multi-symptomatic disease that drives healthcare costs through its complications as the prevalence of this disease grows rapidly world-wide. Real-world electronic health records...

March 05, 2020

RESEARCH PUBLISHED: Ventromedial Hypothalamic Nucleus Neuronal Subset Regulates Blood Glucose Independently of Insulin

ABSTRACT To identify neurons that specifically increase blood glucose from among the diversely-functioning cell types in the ventromedial hypothalamic nucleus (VMN), we studied the cholecystokinin (CCK) receptor-B (CCKBR)-expressing VMN...

February 05, 2020

Developing Beta Cell Imaging Probes to Address Type 1 Diabetes Treatment

One of our newest postdoctoral fellows, Stephane Demine , recently shared with the Indiana Biosciences Research Institute (IBRI) team the benefits of using PET-CT scans. The development of such probes...

January 30, 2020

IBRI RESEARCH PUBLISHED: Exenatide induces frataxin expression and improves mitochondrial function in Friedreich ataxia

Friedreich ataxia (FRDA) is an autosomal recessive neurodegenerative disease with a prevalence of 1/30,000 in Whites. Most patients are homozygous for a GAA trinucleotide repeat expansion in the first intron...

January 29, 2020

How Does Exercise Really Increase Muscle Glucose Uptake?

Associate Research Fellow Carol Witczak, one of the newest members of the Indiana Biosciences Research Institute’s (IBRI) Diabetes Center says, “Yes, but the real question is which facilitative glucose transporter...

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2019 Annual Report cover

The IBRI 2019 Annual Report is now available. The report theme is “Catalyze, Complement, Connect,” which correlates with the IBRI's goals to seek solutions for health problems, enhance the Indiana life sciences ecosystem, and expedite solutions for the most pressing health issues.