January 03, 2020

IBRI RESEARCH PUBLISHED: Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells

Adult human pancreatic beta cells are the “gold standard” for studies on diabetes pathogenesis, but their use is limited by insufficient availability and variable quality. An important effort has recently...

December 03, 2019

IBRI RESEARCH PUBLISHED: Hypusine biosynthesis in ß cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis

Deoxyhypusine synthase (DHPS) uses the polyamine spermidine to catalyze the hypusine modification of the mRNA translation factor eIF5A and promotes oncogenesis through poorly defined mechanisms. Because germline deletion of Dhps...

November 21, 2019

IBRI IN THE NEWS: Researchers working to understand why some patients with autoimmune diseases develop diabetes instead of arthritis

Autoimmune diseases are immune system disorders where the body’s immune system attacks its own tissues. Examples of common autoimmune diseases include rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel disease, type...

November 11, 2019

Autoimmune Diseases: Why Diabetes rather than Arthritis?

INDIANAPOLIS, IND. -- Autoimmune diseases such as type 1 diabetes, rheumatoid arthritis, multiple sclerosis etc., are a case of “mistaken identity;” the immune system that is supposed to protect us...

October 08, 2019

Indiana life sciences organizations partner to launch new information source

Seven Indiana life sciences organizations today launched INscience, a one-stop shop for the sector’s news, events, jobs, and other information via a progressive web app on a mobile device. BioCrossroads,...

July 25, 2019

IBRI announces research team for its Diabetes Center

INDIANAPOLIS, IND. – The Indiana Biosciences Research Institute (IBRI) today announced new investigators for the IBRI Diabetes Center (IDC) . At its first diabetes seminar, held today at Lilly...

June 24, 2019

Interdisciplinary research pushes science in new directions

WEST LAFAYETTE, IND. — A completely new approach to discovering pharmaceutical biologics to fight infectious diseases, new therapies for autism, and exploring a newly discovered intermediate between classical and quantum...

June 20, 2019

IBRI in license agreement for access to Lilly’s Fab Phage Display Library

INDIANAPOLIS, IND. – The Indiana Biosciences Research Institute (IBRI) today announced it has entered into a license agreement with Eli Lilly and Company for the IBRI to access Lilly’s proprietary...

May 28, 2019

Purdue Discovery Park announces Big Idea Challenge 2.0 winners

Following oral presentations on May 7, a panel of judges and Discovery Park administration have reviewed the proposals and determined the winners of the Big Idea Challenge 2.0 , a...

May 10, 2019

IBRI IN THE NEWS: Recently launched research institute pursuing life science innovations through ‘team science’

In a laboratory on the third floor of the Indiana Biosciences Research Institute, researcher Marco Tjioe is squirting liquid into a vial to get a chemical reaction. The next step:...

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2019 Annual Report cover

The IBRI 2019 Annual Report is now available. The report theme is “Catalyze, Complement, Connect,” which correlates with the IBRI's goals to seek solutions for health problems, enhance the Indiana life sciences ecosystem, and expedite solutions for the most pressing health issues.